US Patent Issued to Ionis Pharmaceuticals on Sept. 15 for "Compounds and methods for reducing FUS expression" (California Inventor)

ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,700, issued on Sept. 15, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Compounds and methods for reducing FUS expression" was invented by Huynh-Hoa Bui (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of FUS RNA in a cell or subject, and in certain instances reducing the amount of FUS protein in a cell or subject. These compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a neurodegenerative condition. Such symptoms and hallmarks include muscle weakness and fatigu...