US Patent Issued to Ionis Pharmaceuticals on May 12 for "Compounds and methods for modulating PLP1" (California Inventor)

ALEXANDRIA, Va., May 12 -- United States Patent no. 12,624,356, issued on May 12, was assigned to Ionis Pharmaceuticals Inc. (Carlsbad, Calif.).

"Compounds and methods for modulating PLP1" was invented by Susan M. Freier (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of PLP1 RNA in a cell or subject, and in certain instances reducing the amount of proteolipid protein 1 in a cell or subject. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a leukodystrophy. Such symptoms and hallmarks include hypotonia, nystagmus, optic atrophy, re...