US Patent Issued to INVENTURE on July 28 for "Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents" (Connecticut, Massachusetts Inventors)

ALEXANDRIA, Va., July 28 -- United States Patent no. 12,692,278, issued on July 28, was assigned to INVENTURE LLC (Southbury, Conn.).

"Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents" was invented by Richard J. Deslauriers (Woodbury, Conn.), Michael Milbocker (Holliston, Mass.) and Paul Lombardo (Stamford, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Macrocyclic gadolinium-based contrast agents (GCA) are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species quickly release fre...