US Patent Issued to INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE DE PARIS, INOTREM on July 7 for "TREM-1 inhibitors for the treatment of vaso-occlusions and tissue injuries in patients suffering from sickle cell disease" (French Inventors)

ALEXANDRIA, Va., July 7 -- United States Patent no. 12,673,083, issued on July 7, was assigned to INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (Paris), UNIVERSITE DE PARIS (Paris) and INOTREM (Paris).

"TREM-1 inhibitors for the treatment of vaso-occlusions and tissue injuries in patients suffering from sickle cell disease" was invented by Pierre-Louis Tharaux (Paris), Olivia Lenoir (Paris) and Thomas Mintz (Paris).

According to the abstract* released by the U.S. Patent & Trademark Office: "Sickle cell disease (SCD) is a single gene disorder characterized by mutant hemoglobin-S (HbS) and chronic intravascular haemolysis. Painful vaso-occlusive crises (VOC) are typical of SCD and often associated to a further rise in he...