ALEXANDRIA, Va., April 7 -- United States Patent no. 12,595,219, issued on April 7, was assigned to Indena S.P.A. (Milan).
"Continuos flow synthesis of cannabidiol" was invented by Alessandro Palmieri (Camerino, Italy), Roberto Ballini (Camerino, Italy), Pietro Allegrini (Milan) and Daniele Ciceri (Milan).
According to the abstract* released by the U.S. Patent & Trademark Office: "A process for the synthesis of Cannabidiol of formula (1): (1) is herein disclosed. The process comprises contacting a solution [solution (S1)] of (+)-p-mentha-diene-3-ol of formula (4) (4) or an ester thereof and olivetol of formula (3): (3) with a solution [solution (S2)] of a non-supported Lewis acid in a continuous flow reactor and treatment of the resulting...