US Patent Issued to HUASHAN HOSPITAL AFFILIAED TO FUDAN UNIVERSITY on May 19 for "Genetically modified rat having PKHD1L1 gene with point mutation and methods for its construction, detection and use" (Chinese Inventors)

ALEXANDRIA, Va., May 19 -- United States Patent no. 12,628,802, issued on May 19, was assigned to HUASHAN HOSPITAL AFFILIAED TO FUDAN UNIVERSITY (Shanghai).

"Genetically modified rat having PKHD1L1 gene with point mutation and methods for its construction, detection and use" was invented by Peimin Yu (Shanghai), Xiantao Li (Shanghai), Yimin Sun (Shanghai), Lan Xu (Shanghai) and Yue Wang (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "A genetically-modified rat having a PKHD1L1 gene with a point or other mutation and a construction method thereof are disclosed. A CRISPR/Cas9 system knocks the PKHD1L1 gene into a rat source, and a codon changes from TTA to TCA to construct the mutant PKHD1L1 gene. The...