US Patent Issued to HONGENE BIOTECH on Aug. 4 for "T4 RNA ligase 2 mutants and preparation method and use thereof" (Singaporean Inventors)

ALEXANDRIA, Va., Aug. 5 -- United States Patent no. 12,698,496, issued on Aug. 4, was assigned to HONGENE BIOTECH PTE. LTD. (Singapore).

"T4 RNA ligase 2 mutants and preparation method and use thereof" was invented by Zhipeng Chen (Singapore) and Minzhi Wei (Singapore).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are T4 RNA ligase 2 mutants and preparation method and use thereof, relating to the field of biology and enzyme engineering. The T4 ligase 2 mutants have mutation at least one site of positions 62, 103, 166, 168, 193, 217, 260, 297, 298, 303, 306, 311, 313 and 318 of sequence of the wild-type T4 RNA ligase 2. Compared with the wild type, the mutants have remarkably improved thermal stabili...