ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,293, issued on March 17, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).
"Method for the expression of polypeptides using modified nucleic acids" was invented by Stefan Klostermann (Neuried, Germany), Erhard Kopetzki (Penzberg, Germany) and Ursula Schwarz (Eurasburg, Germany).
According to the abstract* released by the U.S. Patent & Trademark Office: "Herein is reported a method for recombinantly producing a polypeptide in a cell comprising the step of cultivating a cell which comprises a nucleic acid encoding the polypeptide, and recovering the polypeptide from the cell or the cultivation medium, wherein each of the amino acid residues of the polypeptide is encoded...