ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,257, issued on March 17, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Heterocyclic compounds" was invented by Bernd Kuhn (Basel, Switzerland), Uwe Grether (Basel, Switzerland), Benoit Hornsperger (Basel, Switzerland), Hans Richter (Basel, Switzerland), Carsten Kroll (Basel, Switzerland), Katrin Groebke Zbinden (Basel, Switzerland), Fionn O'Hara (Basel, Switzerland), Didier Rombach (Basel, Switzerland) and Marius Daniel Rinaldo Lutz (Basel, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides new heterocyclic compounds having the general formula (I)wherein A, B, L, X, R1, R2, R3 and R4 are as described h...