US Patent Issued to Hoffmann-La Roche on Aug. 4 for "Method for selection and production of multi-specific targeting entities containing at least an antibody fc-region and an antigen binding peptide and uses thereof" (German Inventors)

ALEXANDRIA, Va., Aug. 5 -- United States Patent no. 12,698,332, issued on Aug. 4, was assigned to Hoffmann-La Roche Inc. (Little Falls, N.J.).

"Method for selection and production of multi-specific targeting entities containing at least an antibody fc-region and an antigen binding peptide and uses thereof" was invented by Sebastian Fenn (Munich), Erhard Kopetzki (Penzberg, Germany) and Georg Tiefenthaler (Sindelsdorf, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Herein are reported antibody Fc-region conjugates useful for the treatment of disease and methods for producing the same comprising incubating under conditions that allow for sortase mediated transpeptidation: (i) a dimeric antibody heavy c...