ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,746,413, issued on Sept. 29, was assigned to HISTOSONICS INC. (Plymouth, Minn.) and THE REGENTS OF THE UNIVERSITY OF MICHIGAN (Ann Arbor, Mich.).

"Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering" was invented by Jonathan M. Cannata (Ann Arbor, Mich.), Timothy L. Hall (Ann Arbor, Mich.), Adam D. Maxwell (Ann Arbor, Mich.) and Dejan Teofilovic (Ann Arbor, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasou...