US Patent Issued to Health Research on Feb. 17 for "Treatment of P53-deficient cancers" (New York Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,551,498, issued on Feb. 17, was assigned to Health Research Inc. (Buffalo, N.Y.).

"Treatment of P53-deficient cancers" was invented by Andrei Bakin (Buffalo, N.Y.) and Justin Zonneville (Webster, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided are methods and formulations for the treatment of p53-deficient cancers using a combinational drug strategy which enhances DNA damage in p53 deficient cells while not allowing cells to escape cell death by activation of p53-p21 signaling. Wild-type p53 carriers, on the other hand, respond with activation of p53-p21 signaling and cell-cycle arrest, thereby escaping cell death. The methods involve admin...