US Patent Issued to H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE on Sept. 8 for "Artificial antigen presenting cells for genetic engineering of immune cells" (Florida Inventor)

ALEXANDRIA, Va., Sept. 8 -- United States Patent no. 12,729,232, issued on Sept. 8, was assigned to H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. (Tampa, Fla.).

"Artificial antigen presenting cells for genetic engineering of immune cells" was invented by Marco Davila (Tampa, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are methods of producing chimeric antigen receptor (CAR) T cells using substrates, such as artificial antigen presenting cells, containing on a surface a a heparin binding domain (HBD), anti-CD3 single chain antibodies, anti-CD28 single chain antibodies (scFv), and optionally anti-41BBL antibodies. Anti-CD3 and Anti-CD28 scFvs bind and activate expanding T ce...