US Patent Issued to H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE on May 12 for "Engineering broadly reactive human notch ligands as novel tools for biomedical applications" (Florida Inventors)

ALEXANDRIA, Va., May 12 -- United States Patent no. 12,624,072, issued on May 12, was assigned to H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. (Tampa, Fla.).

"Engineering broadly reactive human notch ligands as novel tools for biomedical applications" was invented by Vincent Luca (Tampa, Fla.) and David Gonzalez Perez (Tampa, Fla.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compositions and methods for engineered DLL4 proteins. In one aspect, disclosed herein are engineered DLL4 proteins comprising a conservative amino acid substitution at a residue corresponding to residues 28, 107, 143, 194, and 206 as set forth in SEQ ID NO: 1 and further comprising at least one conservative a...