ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,482, issued on Sept. 15, was assigned to GRACELL BIOSCIENCE (SHANGHAI) Co. LTD. (Shanghai).
"Humanized CD19 antibody and use thereof" was invented by Hua Zhang (Shanghai), Lianjun Shen (Shanghai), Huan Shi (Shanghai), Wei Cao (Shanghai) and Wenjie Yin (Shanghai).
According to the abstract* released by the U.S. Patent & Trademark Office: "A humanized CD 19 antibody, and a chimeric antigen receptor thereof, an immune cell thereof and the use thereof are provided. The humanized CD19 antibody is based on a FMC63 chimeric antibody, which is subjected to humanization modification. A CAR-T and a dual CAR-T cell constructed based on the humanized antibody and the related use thereof are...