US Patent Issued to GENZYME on Sept. 15 for "Modified adeno-associated viral capsid proteins for ocular gene therapy and methods of use thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,459, issued on Sept. 15, was assigned to GENZYME Corp. (Cambridge, Mass.).

"Modified adeno-associated viral capsid proteins for ocular gene therapy and methods of use thereof" was invented by Amy Frederick (Cambridge, Mass.), Xiaoying Jin (Cambridge, Mass.), Lin Liu (Cambridge, Mass.), Catherine O'Riordan (Cambridge, Mass.) and Jennifer Sullivan (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are modified adeno-associated viral (AAV) capsid proteins, compositions (e.g., rAAV) comprising the capsid proteins, and nucleic acids encoding the capsid proteins. The AAV capsids provided herein confer retinal cell tropism an...