ALEXANDRIA, Va., March 24 -- United States Patent no. 12,584,903, issued on March 24, was assigned to Gentium S.R.L. (Villa Guardia, Italy).
"Cellular-based method for determining the potency of defibrotide" was invented by Terenzio Ignoni (San Fermo Della Battaglia, Italy), Vijay Kumar (Casnate, Italy) and Claudio Verga (Bregnano, Italy).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to cell-based methods for determining the biological activity of defibrotide. In particular, the invention provides a method for assessing the potency of defibrotide by assessing the viability of mammalian cells in the presence of at least one cytotoxic agent and one or more concentrations of defibr...