US Patent Issued to Genentech on Feb. 24 for "Methods of producing polypeptides using a cell line resistant to apoptosis" (California Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,781, issued on Feb. 24, was assigned to Genentech Inc. (South San Francisco, Calif.).

"Methods of producing polypeptides using a cell line resistant to apoptosis" was invented by Tia Alexandra Arena (San Francisco) and Athena W. Wong (Burlingame, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are cell lines (e.g., HEK293 cell lines) that comprise a loss-of-function mutation in each of the human Bax and Bak genes, as well as cell cultures comprising the cell lines. The cell lines and/or cell cultures may find use, e.g., in methods for producing a recombinant polypeptide (such as an antibody or antigen-binding fragment thereof) ...