ALEXANDRIA, Va., Aug. 25 -- United States Patent no. 12,716,088, issued on Aug. 25, was assigned to GEN-PROBE Inc. (San Diego).

"Method and system for performing a cumulative nucleic acid amplification reaction" was invented by Anne Niinivaara (Vantaa, Finland), Juha Saharinen (Espoo, Finland) and Juha Kirveskari (Espoo, Finland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed to a nucleic acid amplification based method for determining the presence or absence of a target polynucleotide in a sample, wherein a portion of the amplified reaction mix is replaced with a further portion of the sample between pre-amplification steps to obtain a mix of an amplified reaction and an un...