ALEXANDRIA, Va., Aug. 25 -- United States Patent no. 12,715,865, issued on Aug. 25, was assigned to EVOTEC INTERNATIONAL GMBH (Hamburg, Germany).

"Modulators of the integrated stress response pathway" was invented by Christopher John Brown (Abingdon, Great Britain), James Lindsay Carr (Abingdon, Great Britain), Mohamad Sabbah (Abingdon, Great Britain), Jeffrey Michael Schkeryantz (Lawrence Township, N.J.) and Daryl Simon Walter (Abingdon, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra4, Ra5, X1, X1a, A1 and ...