US Patent Issued to DENALI THERAPEUTICS on May 26 for "Anti-transferrin receptor fusion proteins and methods of use thereof" (California Inventors)

ALEXANDRIA, Va., May 26 -- United States Patent no. 12,636,363, issued on May 26, was assigned to DENALI THERAPEUTICS INC. (South San Francisco, Calif.).

"Anti-transferrin receptor fusion proteins and methods of use thereof" was invented by Annie Arguello (San Francisco), Tina Giese (South San Francisco, Calif.), Gunasekaran Kannan (Daly City, Calif.), Mihalis S. Kariolis (San Mateo, Calif.), Cathal S. Mahon (San Francisco) and Junhua Wang (Fremont, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferr...