US Patent Issued to DANA-FARBER CANCER INSTITUTE on Oct. 27 for "Phthalimido cereblon complex binders and transcription factor degraders and methods of use" (Massachusetts Inventors)

ALEXANDRIA, Va., Oct. 27 -- United States Patent no. 12,774,279, issued on Oct. 27, was assigned to DANA-FARBER CANCER INSTITUTE INC. (Boston).

"Phthalimido cereblon complex binders and transcription factor degraders and methods of use" was invented by Tinghu Zhang (Brookline, Mass.), Lyn Howard Jones (Winchester, Mass.), Hu Liu (Newton, Mass.) and Jianwei Che (Sharon, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that may bind to CRBN complex and cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds ...