US Patent Issued to ClearNote Health on March 24 for "Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use" (California Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,584,162, issued on March 24, was assigned to ClearNote Health Inc. (San Diego).

"Hydroxymethylation analysis of cell-free nucleic acid samples for assigning tissue of origin, and related methods of use" was invented by Chin-Jen Ku (San Francisco), Francois Collin (San Francisco), Patrick Arensdorf (Palo Alto, Calif.) and Samuel Levy (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method is provided for probabilistically assigning a tissue of origin to a nucleic acid in a sample, e.g., DNA in a cell-free fluid sample obtained from a human subject. A hydroxymethylation profile is generated for the sample DNA and then compared across a referen...