US Patent Issued to City of Hope on Oct. 6 for "CCR4 targeted chimeric antigen receptor modified T cells for treatment of CCR4 positive malignancies" (California Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,753,219, issued on Oct. 6, was assigned to City of Hope (Duarte, Calif.).

"CCR4 targeted chimeric antigen receptor modified T cells for treatment of CCR4 positive malignancies" was invented by Lihua Elizabeth Budde (Duarte, Calif.), Marissa M. Del Real (Duarte, Calif.) and Stephen Forman (Duarte, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Chimeric antigen receptors (CAR) for use in treating lymphoma-associated C-C chemokine receptor type 4 (CCR4) and other cancers expressing CCR4 comprise a CCR4 targeting domain (i.e., a CCR4 targeted single chain variable fragment or variant thereof). A population of autologous or allogeneic T cells expressin...