ALEXANDRIA, Va., June 16 -- United States Patent no. 12,653,529, issued on June 16, was assigned to Cilag GmbH International (Zug, Switzerland).

"Applicator instruments with inverted handles and triggers, curved shafts, and visible orientation indicia" was invented by Michael Cardinale (Flemington, N.J.), Doug Souls (Andover, N.J.), Simon Cohn (Lebanon, N.J.), Matthew Rohr Daniel (San Francisco), Jonathan B. Gabel (Randolph, N.J.) and Danial Paul Ferreira (Milford, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "An applicator instrument for dispensing surgical fasteners includes a housing, a firing system moveable along a first axis, a handle extending upwardly from the housing along a second axis that ...