US Patent Issued to Chugai Seiyaku on June 2 for "Fc region variant" (Japanese Inventors)

ALEXANDRIA, Va., June 2 -- United States Patent no. 12,643,937, issued on June 2, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Fc region variant" was invented by Futa Mimoto (Shizuoka, Japan), Hitoshi Katada (Shizuoka, Japan) and Tomoyuki Igawa (Shizuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "A polypeptide containing an antibody Fc region variant which has an amino acid sequence in which an amino acid alteration at position 238 according to EU numbering is combined with other specific amino acid alteration(s), was found to have decreased binding activities to all activating FcGammaRs, in particular FcGammaRIIa (R type), while maintaining its FcGammaRIIb-binding activity, when compared to a po...