US Patent Issued to Chugai Seiyaku on July 28 for "Methods of modifying antibodies for purification of bispecific antibodies" (Japanese Inventors)

ALEXANDRIA, Va., July 28 -- United States Patent no. RE50,968, issued on July 28, was assigned to Chugai Seiyaku K.K. (Tokyo).

"Methods of modifying antibodies for purification of bispecific antibodies" was invented by Tomoyuki Igawa (Shizuoka, Japan) and Hiroyuki Tsunoda (Shizuoka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present inventors devised methods for efficiently purifying bispecific antibodies using a chromatography column based on the difference in isoelectric points between the H chains of two types of antibodies, wherein the difference is introduced by modifying the amino acids present on the surface of the antibody variable regions of two types of antibodies that constitute a bi...