US Patent Issued to Children's Medical Center on Feb. 24 for "ApoM-Fc fusion proteins and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,540, issued on Feb. 24, was assigned to Children's Medical Center Corp. (Boston).

"ApoM-Fc fusion proteins and uses thereof" was invented by Timothy T. Hla (Wellesley, Mass.), Steven L. Swendeman (Cambridge, Mass.) and Lois Smith (West Newton, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are engineered fusion proteins comprising ApoM (e.g., human or murine ApoM) fused to a constant region (Fc) of a immunoglobulin G (IgG, e.g., human IgG or murine IgG). In some embodiments, the ApoM-Fc fusion protein further comprises a signal peptide (e.g., IL-2 signal peptide) fused to the ApoM, allowing the fusion protein to be secreted onc...