US Patent Issued to Children's Medical Center on Aug. 25 for "Compounds for inhibition of inflammation" (Massachusetts Inventors)

ALEXANDRIA, Va., Aug. 25 -- United States Patent no. 12,714,716, issued on Aug. 25, was assigned to Children's Medical Center Corp. (Boston).

"Compounds for inhibition of inflammation" was invented by Hao Wu (Brookline, Mass.), Judy Lieberman (Brookline, Mass.), Jun Hu (Boston) and Xing Liu (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides chemical compounds useful, for example, in inhibiting gasdermin pore formation in a CA cell, inhibiting inflammasome-mediated death of a cell (pyroptosis); inhibiting cytokine secretion from a cell, inhibiting an inflammatory caspase in a cell, and/or covalently reacting with a cysteine of a gasdermin protein in a cell. These compounds...