US Patent Issued to Brown University on June 9 for "Bispecific antibodies against CHI3L1 and PD1 with enhanced T cell-mediated cytotoxic effects on tumor cells" (Rhode Island, Connecticut Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,649,792, issued on June 9, was assigned to Brown University (Providence, R.I.).

"Bispecific antibodies against CHI3L1 and PD1 with enhanced T cell-mediated cytotoxic effects on tumor cells" was invented by Jack A. Elias (Providence, R.I.), Chun Geun Lee (Providence, Conn.) and Suchitra Kamle (Providence, R.I.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are bispecific antibodies simultaneously targeting both CHI3L1 and the immune checkpoint molecule PD-1. These antibodies manifest enhanced synergistic cytotoxic effects compared to the effects of individual CHI3L1 and PD-1 antibodies, alone or in combination. Methods of treating a cance...