US Patent Issued to BRIDGENE BIOSCIENCES on March 24 for "Inhibitors of YAP/TAZ-TEAD oncoproteins, synthesis and use thereof" (California Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,815, issued on March 24, was assigned to BRIDGENE BIOSCIENCES INC. (San Jose, Calif.).

"Inhibitors of YAP/TAZ-TEAD oncoproteins, synthesis and use thereof" was invented by Chao Zhang (Monterey Park, Calif.), Michael J. Bishop (San Diego), Hang Chen (San Jose, Calif.) and Ping Cao (San Jose, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are synthesis and use of covalent inhibitors selective for Transcriptional Enhancer Factor TEF-1 (TEAD1), which can be used for treatment of cancers such as glioblastoma, gastric cancer, colorectal cancer, pancreatic ductal adenocarcinoma (PDAC), and malignant pleural mesothelioma (MPM). Furt...