US Patent Issued to Brandeis University on Aug. 18 for "Tethering cysteine residues using cyclic disulfides" (Rhode Island, Massachusetts Inventors)

ALEXANDRIA, Va., Aug. 18 -- United States Patent no. 12,709,745, issued on Aug. 18, was assigned to Brandeis University (Waltham, Mass.).

"Tethering cysteine residues using cyclic disulfides" was invented by Jeffrey N. Agar (Newton, Mass.) and Joseph Salisbury (Cranston, R.I.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization."

The patent was filed on May 16, 2...