ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,551,544, issued on Feb. 17, was assigned to BIOMVIS SRL (Siena, Italy).

"Method for the production of outer membrane vesicles and immunogenic compositions thereof" was invented by Guido Grandi (Segrate, Italy), Alberto Grandi (Siena, Italy), Laura Fantappie' (Siena, Italy), Ilaria Zanella (Trento, Italy), Enrico Koenig (Trento, Italy) and Assunta Gagliardi (Trento, Italy).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to gram-negative bacteria carrying gene-inactivating mutations that cause deletion of proteins belonging to the OMV proteome, to Outer Membrane Vesicles (OMVs) produced by these bacteria and immunogenic compositions th...