US Patent Issued to AUTOLUS on July 28 for "Chimeric antigen receptor (CAR) comprising a CD19-binding domain" (British Inventors)

ALEXANDRIA, Va., July 28 -- United States Patent no. 12,692,313, issued on July 28, was assigned to AUTOLUS Ltd. (London).

"Chimeric antigen receptor (CAR) comprising a CD19-binding domain" was invented by Martin Pule (London), Leila Mekkaoui (London), Persis Amrolia (London), Sara Ghorashian (London), Anne Kramer (London) and Gordon Cheung (London).

According to the abstract* released by the U.S. Patent & Trademark Office: "There is provided a chimeric antigen receptor (CAR) comprising a CD19-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: CDR1-GY-AFSSS (SEQ ID No. 1); CDR2-YPGDED (SEQ ID No. 2) CDR3-SLLYGDYLDY (SEQ ID No. 3); and b) a li...