ALEXANDRIA, Va., April 15 -- United States Patent no. 12,600,969, issued on April 14, was assigned to Askbio Inc. (Research Triangle Park, N.C.).
"Expression control using a regulatable intron" was invented by Graham Whyteside (Falkirk, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to the use of a regulatory nucleic acid sequences that are able to regulate gene expression in eukaryotic cells and which are responsive to the unfolded protein response (UPR). There are disclosed regulatable introns and UPR-inducible promoters, which are able to regulate gene expression. There are also disclosed recombinant expression constructs comprising such regulatory nucleic acid ...