US Patent Issued to ARVINAS OPERATIONS on April 7 for "Modulators of alpha-synuclein proteolysis and associated methods of use" (Connecticut, New Jersey Inventors)

ALEXANDRIA, Va., April 7 -- United States Patent no. 12,594,264, issued on April 7, was assigned to ARVINAS OPERATIONS INC. (New Haven, Conn.).

"Modulators of alpha-synuclein proteolysis and associated methods of use" was invented by Andrew P. Crew (Guilford, Conn.), Hanqing Dong (Madison, Conn.), Michael Berlin (Flemington, N.J.) and Steven M. Sparks (Guilford, Conn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to bifunctional compounds, which find utility as modulators of Alpha-synuclein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon. Inhibitors of Apotosis Proteins or mou...