ALEXANDRIA, Va., April 7 -- United States Patent no. 12,594,388, issued on April 7, was assigned to AptarGroup Inc. (Crystal Lake, Ill.).

"Device to deliver a predetermined amount of a substance to a natural orifice of the body" was invented by Daniel Shahaf (M.P. Emek Ha-Yarden, Israel) and Iris Shichor (Zichron Yaakov, Israel).

According to the abstract* released by the U.S. Patent & Trademark Office: "A device for delivering a predetermined amount of at least one substance to a body orifice of a subject includes a) a container for containing said at least one substance; b) a delivery end for placement in proximity to the orifice, the delivery end being in fluid communication with the container; c) a valve mechanically connectable to sa...