US Patent Issued to AO TECHNOLOGY on April 14 for "Method of determining or influencing the chondrogenic potential of mesenchymal stromal cells" (Swiss Inventors)

ALEXANDRIA, Va., April 15 -- United States Patent no. 12,600,952, issued on April 14, was assigned to AO TECHNOLOGY AG (Chur, Switzerland).

"Method of determining or influencing the chondrogenic potential of mesenchymal stromal cells" was invented by Martin Stoddart (Davos Dorf, Switzerland) and Mauro Alini (Porto Ronco, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method of increasing the chondrogenic potential mediated by TGFBeta of a mesenchymal stromal cell (MSC) or a population of mesenchymal stromal cells (MSCs), comprising the step of increasing the amount of TGFBetaR1, and/or decreasing the amount of TGFBetaR2, and/or decreasing the amount of and/or ACVRL1 of the MSC or a population o...