US Patent Issued to Amgen on Feb. 17 for "Diol desymmetrization by nucleophilic aromatic substitution" (Massachusetts, California Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,552,808, issued on Feb. 17, was assigned to Amgen Inc. (Thousand Oaks, Calif.).

"Diol desymmetrization by nucleophilic aromatic substitution" was invented by Matthew G. Beaver (Natick, Mass.), Joseph Michael Dennis (San Diego), Peter Dornan (Stoneham, Mass.), Steven Mennen (Boston), Jason S. Tedrow (Salem, Mass.), Neil F. Langille (Sudbury, Mass.), Carolyn Michelle Cohen (Somerville, Mass.) and Andreas Rene Rotheli (Wellesley, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound Y that can be used to prepare them where the variable R1 is as defined herein....