ALEXANDRIA, Va., April 7 -- United States Patent no. 12,594,342, issued on April 7, was assigned to Amgen Inc. (Thousand Oaks, Calif.).
"Method of conjugation of Cys-mAbs" was invented by Michal Achmatowicz (Simi Valley, Calif.), Dante Romanini (Sherman Oaks, Calif.), James R. Falsey (Moorpark, Calif.), Bradley J. Herberich (Newbury Park, Calif.) and Oliver R. Thiel (Thousand Oaks, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to a method of capping, reducing, and oxidizing cys-mAbs in order to provide homogenous material for subsequent conjugation reactions. The present method demonstrates robust ways to manufacture conjugates of cysteine-engineered antibodies that off...