US Patent Issued to Amgen on April 14 for "Use of low molecular weight polyvinylpyrrolidone (PVP) to reduce viscosity of high concentration protein formulations" (California Inventor)

ALEXANDRIA, Va., April 15 -- United States Patent no. 12,599,669, issued on April 14, was assigned to Amgen Inc. (Thousand Oaks, Calif.).

"Use of low molecular weight polyvinylpyrrolidone (PVP) to reduce viscosity of high concentration protein formulations" was invented by Christopher James Sloey (Newbury Park, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein are pharmaceutical compositions (formulations) having reduced viscosity, using a low molecular weight polyvinylpyrrolidone (povidone) in the case of high therapeutic protein concentration (less than=70 mg/ml) formulations. The addition of arginine, such as arginine monohydrochloride or N-acetyl arginine, can further reduce viscosit...