US Patent Issued to ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS on Feb. 24 for "Induction of hepatocytes by stem cell differentiation with RNA" (California Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,729, issued on Feb. 24, was assigned to ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS INC. (San Diego).

"Induction of hepatocytes by stem cell differentiation with RNA" was invented by Jiwu Wang (La Jolla, Calif.), Yuhui Ni (San Diego) and Yuanyuan Zhao (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "A novel method of inducing or producing hepatocytes from human induced pluripotent stem cells at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered mRNAs at multiple critical differentiation decision points along a pluripotent to mesendoderm to endoderm to hepatocytes pathway in a previo...