ALEXANDRIA, Va., April 15 -- United States Patent no. 12,600,984, issued on April 14, was assigned to Aldevron LLC (South Fargo, N.D.).
"Viral and non-viral nanoplasmid vectors with improved production" was invented by James A. Williams (Lincoln, Neb.).
According to the abstract* released by the U.S. Patent & Trademark Office: "A method for improving the replication of a covalently closed circular plasmid is provided. The method includes providing a covalently closed circular plasmid having a Pol I-dependent origin of replication, and an insert including a structured DNA sequence selected from inverted repeat sequences, direct repeat sequences, homopolymeric repeat sequences, eukaryotic origins of replication or eukaryotic promoter enhanc...