ALEXANDRIA, Va., June 16 -- United States Patent no. 12,655,110, issued on June 16, was assigned to AIC246 AG & Co. KG (Wuppertal, Germany).
"Method of producing a crystalline form of sodium 2-[(4S)-8-fluoro-2-[4-(3- methoxyphenyl)piperazin-1-yl-3-[2-methoxy-5-(trifluoromethyl)phenyl-4H-quinazoline-4-ylacetate trihydrate" was invented by Helmut Buschmann (Aachen, Germany), Thomas Goldner (Velbert, Germany) and Jordi Carles Ceron Bertran (La Pobla de Montornes, Spain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention refers to an effective method of preparing a crystalline form of 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl) phenyl]-4H-quinazolin-4-...