US Patent Issued to ACADEMIA SINICA on April 21 for "PDIA4 inhibitors and use thereof for inhibiting Beta-cell pathogenesis and treating diabetes" (Taiwanese Inventors)

ALEXANDRIA, Va., April 21 -- United States Patent no. 12,605,353, issued on April 21, was assigned to ACADEMIA SINICA (Taipei City, Taiwan).

"PDIA4 inhibitors and use thereof for inhibiting Beta-cell pathogenesis and treating diabetes" was invented by Wen-Chin Yang (Taichung County, Taiwan) and Keng-Chang Tsai (Taipei City, Taiwan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic Beta-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 MuM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic Beta-cells. The ...