US Patent Issued to AAVnerGene on March 24 for "Modified plasma clotting factor VIII and method of use thereof" (Maryland Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,907, issued on March 24, was assigned to AAVnerGene INC. (Rockville, Md.).

"Modified plasma clotting factor VIII and method of use thereof" was invented by Qizhao Wang (Rockville, Md.) and Daozhan Yu (Ellicott City, Md.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Modified human factor VIII polypeptides with enhanced factor VIII activity are described. In some embodiments, the modified human factor VIII polypeptides comprise one or more amino acid substitutions at positions A20, T21, F57, L69, I80, L178, R199, H212, I215, R269, I310, L318, S332, R378, I610 and/or I661. Such polypeptides and viral vectors encoding such polypeptides may be used for...