US Patent Issued on Sept. 22 for "Conjugates of guide RNA-Cas protein complex" (California Inventor)

ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,742,162, issued on Sept. 22.

"Conjugates of guide RNA-Cas protein complex" was invented by Minghong Zhong (Burlingame, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compositions of conjugates of a guide RNA(s)-CRISPR Cas protein (RNP) complex. The conjugate comprises a guide RNA(s)-CRISPR Cas protein (RNP) complex and one or more molecules selected from PEG, non-PEG polymers, ligands for cellular receptors, lipids, oligonucleotides, polysaccharides and peptides and chemically linked to the Cas protein and/or guide RNA(s). The conjugates are delivered to targeted cells as RNP complexes, or formed in targeted cells from guide ...