US Patent Issued on June 2 for "Chimeric protein toxins for expression by therapeutic bacteria" (California Inventor)

ALEXANDRIA, Va., June 2 -- United States Patent no. 12,642,873, issued on June 2.

"Chimeric protein toxins for expression by therapeutic bacteria" was invented by David Gordon Bermudes (Woodland Hills, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Bacteria with tumor-targeting capability express, surface displayed, secreted and/or released modified chimeric therapeutic proteins with enhanced therapeutic activity against a neoplastic tissue including solid tumors, lymphomas and leukemias. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. The chimeric proteins may be protease sensitive and may optionally be further accompanied by co-expression of a secreted protease inhibit...