US Patent Issued on July 7 for "Method of ligation for the detection of abasic sites on a DNA target sequence" (Canadian Inventors)

ALEXANDRIA, Va., July 7 -- United States Patent no. 12,674,191, issued on July 7.

"Method of ligation for the detection of abasic sites on a DNA target sequence" was invented by Julianne M. Gibbs-Davis (Edmonton/Alberta, Canada) and Hansol Park (Totonto, Canada).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method of ligating a ligation product for detecting abasic sites on DNA target sequence is described. The ligation method uses a pyrene probe that ligates with a second probe in the presence of a ligase. A pyrene may comprise 5'-phosphate 1'-pyrene deoxyribonucleotide at the 5'-terminus. The second probe may comprise a terminal 3'-hydroxy, wherein the 3'-hydroxy is ligated with the pyrene probe. The lig...