US Patent Issued on Feb. 17 for "Sensitive oligonucleotide synthesis using sulfur-based functions as protecting groups and linkers" (Michigan Inventor)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,552,828, issued on Feb. 17.

"Sensitive oligonucleotide synthesis using sulfur-based functions as protecting groups and linkers" was invented by Shiyue Fang (Houghotn, Mich.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Embodiments for the synthesis of sensitive oligonucleotides as well as insensitive oligonucleotides are provided. Sulfur-based groups are used for the protection of exo-amino groups of nucleobases, phosphate groups and 2'-OH groups, and as cleavable linker for linking oligonucleotides to a support. Oligonucleotide syntheses are achieved under typical conditions using phosphoramidite chemistry with important modifications. To prevent repl...